Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells
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چکیده
منابع مشابه
Increased antibody productivity in Chinese Hamster Ovary cells through induction of chromosomal instability by cell fusion
Background Chromosomal instability, which often occurs as a random event in an uncontrollable manner, is a key characteristic of Chinese Hamster Ovary (CHO) cells. This often complicates the process of establishing stable, high antibody-producing CHO cell lines. We previously found that the abnormal increase of chromosome number is linked to increased antibody production in adherent CHO DG44 ce...
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HIPK2, a cell fate decision kinase inactivated in several human cancers, is thought to exert its oncosuppressing activity through its p53-dependent and -independent apoptotic function. However, a HIPK2 role in cell proliferation has also been described. In particular, HIPK2 is required to complete cytokinesis and impaired HIPK2 expression results in cytokinesis failure and tetraploidization. Si...
متن کاملThe chemokine GRO-alpha (CXCL1) confers increased tumorigenicity to glioma cells.
The chemokine GRO-alpha (CXCL1) has been found to mediate the proliferation of glia progenitor cells during neural development. As malignant gliomas are thought to arise from glia progenitors or their differentiated counterparts, astrocytes or oligodendrocytes, we have investigated whether GRO-alpha regulates the tumor characteristics of glioma cells. We found first that resected glioma specime...
متن کاملIncreased Notch Signaling Enhances Radioresistance of Malignant Stromal Cells Induced by Glioma Stem/ Progenitor Cells
BACKGROUND Host malignant stromal cells induced by glioma stem/progenitor cells were revealed to be more radiation-resistant than the glioma stem/progenitor cells themselves after malignant transformation in nude mice. However, the mechanism underlying this phenomenon remains unclear. METHODS Malignant stromal cells induced by glioma stem/progenitor cell 2 (GSC-induced host brain tumor cells,...
متن کاملChromosomal instability in unirradiated cells induced in vivo by a bystander effect of ionizing radiation.
Using a bone marrow transplantation protocol in which we transplanted a mixture of irradiated and nonirradiated bone marrow cells that were distinguishable by a cytogenetic marker, we have demonstrated chromosomal instability in the progeny of nonirradiated hemopoietic stem cells. This first demonstration of a link between a bystander effect of ionizing radiation and the induction of genomic in...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2017
ISSN: 1471-2407
DOI: 10.1186/s12885-017-3932-y